+ Research Scientist

ViewPoint is in search of a self-motivated, talented, entrepreneurial Research Scientist interested in joining a fast-paced and dynamic research group. The preferred candidate will be expected to design and carry out studies to characterize new drug candidates and elucidate their mechanism of action using biophysical, biochemical, and cellular biology techniques. Additionally, the candidate will be involved in early-stage studies to explore new indications that relate to ViewPoint’s focus on protein misfolding diseases.

The successful candidate should have a doctoral degree in biochemistry, biophysics, cellular biology, or related subject in the life sciences (Ph.D.) and at least 3 years of working in a biotechnology environment. Ideally, they will also have experience using biophysical/biochemical in vitro techniques and experience studying small molecules in cell models and systems.

Job responsibilities:

  • Characterize protein-ligand interactions and protein-protein interactions with biochemical and biophysical assays (e.g. DSF, SPR, MST, FRET, enzymatic)
  • Develop relevant cell models of protein misfolding diseases and characterize the activity of drug candidates using fluorescence microscopy, flow cytometry, or other relevant techniques
  • Keep an accurate and up-to-date laboratory notebook and contribute to periodic technical reports and manuscripts
  • Present results to project leaders and participate in discussions of research strategy on a routine basis
  • Interact in a collaborative manner with other team members to accomplish organizational goals


Job responsibilities may also include:

  • Develop quantitative biophysical ligand binding assays for use in driving medicinal chemistry optimization
  • Assist in characterizing small molecules using standard analytical techniques (e.g. HPLC/MS, proton and carbon NMR)
  • Dissect tissues and carry out assays using protein extracts
  • Dissect tissues and carry out ex vivo pharmacokinetic assessments
  • Present results at technical meetings and to ViewPoint’s Board of Directors and Scientific Advisory Board

Personal qualifications:

  • Entrepreneurial spirit with willingness to work as a member of a small and versatile team

  • Strong interpersonal skills and ability to instill and earn trust quickly with teams, partners, and collaborators.

  • Strong leadership and motivational capabilities.

  • Clear written and verbal communication skills. Must be able to communicate effectively with business partners, senior executive leadership, direct reports, and external collaborators clearly and credibly.

  • Flexible and adaptable style, with a willingness to take on new challenges and resilience to respond to emerging challenges

  • High level of integrity and honesty

ViewPoint is an equal opportunity employer.

Benefits:

Competitive salary, commensurate with experience

Stock compensation plan

Excellent health, dental, and vision benefits

Flexible work schedule

Job Type:

Full-time

If you are interested, we’d love to hear from you. Please forward all resumes with cover letters to:

jobs@viewpointtherapeutics.com

+ Research Associate

ViewPoint is in search of a self-motivated, talented, detail-oriented Research Associate to join our discovery research group in a full-time position. We have a small team, so this is an opportunity to make a significant impact on the early trajectory of a venture-backed startup and to grow along with our company.

The successful candidate should have a bachelor of science degree in biochemistry, cellular biology, molecular biology, or related subject (BS) and at least 2 years of laboratory research experience. Ideally, they will also have have developed skills with in vitro protein characterization and/or cellular biology.

Job responsibilities:

  • Conduct recombinant protein production and purification
  • Assist with the preparation of reagents for biophysical and biochemical assays
  • Carry out biophysical and biochemical assays to characterize drug candidates
  • Maintain mammalian cell cultures and perform routine cytotoxicity experiments
  • Assist with studies using cultured cells, tissue extracts, and whole tissue
  • Analyze experimental data using GraphPad Prism and the Microsoft Office Suite
  • Keep an accurate, detailed, up-to-date laboratory notebook
  • Contribute to technical reports and manuscripts
  • Interact in a collaborative manner with team members to accomplish organizational goals

This list of job duties is not exhaustive and may be revised from time to time per business needs.

Personal qualifications:

  • Proven ability to perform experiments, analyze data, and perform troubleshooting without supervision when needed
  • Experience with programming (Python/R) and/or statistical analysis is a plus
  • Entrepreneurial spirit with willingness to work as a member of a small and versatile team
  • Strong interpersonal skills and ability to instill and earn trust quickly with teams, partners, and collaborators.
  • Strong leadership and motivational capabilities.
  • Clear written and verbal communication skills. Must be able to communicate effectively with business partners, senior executive leadership, direct reports, and external collaborators clearly and credibly.
  • Flexible and adaptable style, with a willingness to take on new challenges and resilience to respond to emerging challenges
  • High level of integrity and honesty

ViewPoint is an equal opportunity employer.

Benefits:

Competitive salary, commensurate with experience

Stock compensation plan

Excellent health, dental, and vision benefits

Flexible work schedule

Job Type: Full-time

If you are interested, we’d love to hear from you. Please forward all resumes with cover letters to:

jobs@viewpointtherapeutics.com

+ Head of Quality Assurance

ViewPoint Therapeutics is a biotechnology company with a mission to translate basic science into innovative therapies and to serve patients around the world. We are focused on the development of small molecule treatments for protein misfolding diseases, including cataracts. ViewPoint is in search of a head of quality assurance to direct and manage a quality program to ensure compliance with internal policies and procedures, applicable regulatory guidelines and applicable, phase-appropriate cGxP.

Education, experience, and desired qualifications:

  • BS or higher degree in science field. Training and experience in cGMP, cGCP, cGLP, regulatory requirements and compliance for small molecule drugs.
  • Minimum of 10 years of relevant and increasingly responsible experience in the biotech/pharmaceutical Industry, specifically within quality or compliance.
  • Pragmatic approach to issue management and risk mitigation planning.
  • Proficient hands-on experience managing quality and compliance-related projects and programs.
  • Proven ability in driving GCP process improvement initiatives.
  • Current and in-depth knowledge and application of phase-appropriate international requirements of Good Clinical Practice (GCP), ICH GCP Guidelines, regulations and compliance initiatives globally applicable to the conduct of clinical trials.
  • Strong knowledge of health authority submission activities, specifically in relation to GCP, for regulatory filings in USA, EU and rest of world.
  • Exemplary cross-functional partnering and collaboration skills.
  • Ability to manage multiple projects in an ever changing, fast-paced environment.
  • Excellent oral and written communication skills for effectively interfacing with other departments within the company, vendors, investigator sites, health authorities, and others.
  • Ability to travel 20-40% domestic and internationally.

Job duties and responsibilities:

  • Establish and maintain phase-appropriate Quality Policies and Quality Manual to reflect ViewPoint’s goals and objectives.
  • Establish and maintain a centralized Document Control System. Ensure adequacy of procedures to ensure document security, archival, retrieval, and record retention.
  • Ensure there are written procedures (SOPs, batch production records, etc.) in place for all GXP work.
  • Review and approve documents, investigate, unexplained discrepancies, failures, and out-of-specification results for products manufactured at or on behalf of ViewPoint. Evaluate the possible impact to process/product and determine batch disposition for release or rejection. This activity ensures that the identity, purity, potency, and quality attributes meet pre-approved acceptance criteria.
  • Oversee the review and approval of documents that support GMP work and regulatory submissions. Responsible for product disposition of GMP batches manufactured by or on behalf of ViewPoint for Clinical Use.
  • Provide Quality Oversight by reviewing and approving change requests as it applies to raw materials, specifications, Method Validation Protocols and Reports, SOPs, analytical test methods, facilities, equipment, processing steps, packaging and labeling, and computerized systems.
  • Review documents provided to Regulatory Affairs for submissions for data accuracy and completeness.
  • Manage GMP Compliance Audits & Regulatory Agency inspections on site. Provide support for Regulatory Agency cGMP inspections on behalf of ViewPoint at CMO sites. Provide response to inspectors for on-site inspections and assist CMO with written responses to observations at their site on behalf of ViewPoint.
  • Oversee Supplier Evaluation, Approval and Management Program from a Quality & cGMP Compliance perspective. Prepare Supplier Audit Plans, for paper and on-site audits, review audit reports for to assure compliance with phase appropriate GMP requirements.
  • Prepare and establish Quality Agreements/Statement of Work with critical suppliers (CMOs, Contractors, etc.). This should indicate the demarcation of responsibilities as it would relate to the GXP compliance requirements.
  • Establish training program and training records for personnel involved with GXP activities.
  • Perform cGMP/GXP training for ViewPoint employees (i.e. data integrity, good documentation practices, basic GMPs, lab notebook usage, etc.) at least once every 12 months.
  • Perform and oversee risk assessments and GXP audits of CMOs/CROs/Contract Labs for evaluation of their Quality Management Systems.
  • Provide Quality support for cGMP facility upgrades and changes.

This list of job duties is not exhaustive and may be revised from time to time per business needs.

Special skills, abilities, and requirements:

  • Must be resourceful, independent, creative, and excited to work in a fast-paced start-up environment.
  • This is a full-time position to be based in the San Francisco Bay Area.
  • Must be eligible to work in the U.S.

ViewPoint is an equal opportunity employer.

Positions Available


 


Careers at Viewpoint

ViewPoint Therapeutics is an early stage biotechnology company with a mission to translate basic science into innovative therapies and to serve patients around the world. We are focused on the development of small molecule treatments for protein misfolding diseases, including cataracts.