Careers at Viewpoint

ViewPoint Therapeutics is an early stage biotechnology company with a mission to translate basic science into innovative therapies and to serve patients around the world. We are focused on the development of small molecule treatments for protein misfolding diseases, including cataracts.
 


Positions Available

+ Director of CMC or Director of Pharmaceutical Product Development

We are looking for a Director of CMC or Director of Pharmaceutical Product Development. This is an opportunity to make a significant impact on the trajectory and success of our company. This individual will be responsible for drug product optimization, manufacturing, and fill/finish in support of preclinical and clinical development activities and will interface with drug substance and analytical function teams.

A successful candidate will have an advanced degree in pharmaceutical sciences or a related field, and will have 7+ years of industry experience in formulation development and a deep understanding of the drug development process. Ideally, they will also have ophthalmic drug development expertise and experience leading technical operations in support of development program(s). An in-depth understanding of ICH guidelines and FDA regulations and experience in IND and NDA filings is required. A successful applicant will also have a demonstrated track record of contributing to both INDs and NDAs.

Job responsibilities:

• Efficiently manage drug product development and manufacturing activities, including with contract research and manufacturing organizations, to support preclinical and clinical studies and regulatory filings

• Potentially represent company in meetings with regulatory agencies

• Work collaboratively to contribute input in the areas of manufacturing, quality, and intellectual property

• Drive prototype formulation discovery and optimization for preclinical leads in pipeline

• Work closely with chemical and analytical development functions

• Oversee consultant/contractor activities

Personal qualifications:

• Entrepreneurial spirit with willingness to work as a member of a small and versatile team

• Strong interpersonal skills and ability to instill and earn trust quickly with teams, partners, and collaborators. Strong leadership and motivational capabilities.

• Clear written and verbal communication skills. Must be able to communicate effectively with business partners, executive leadership, external consultants, and contract research and manufacturing organizations clearly and credibly.

• Flexible and adaptable style, with a willingness to take on new challenges and resilience to respond to emerging challenges

• High level of integrity and honesty

ViewPoint is an equal opportunity employer.

Benefits:

Competitive salary, commensurate with experience

Stock compensation plan

Excellent health, dental, and vision benefits

Flexible work schedule

Projected start date:

ASAP

Job Type:

Full-time

If you are interested, we’d love to hear from you. Please forward all resumes with cover letters to:

jobs@viewpointtherapeutics.com

+ Associate Director of Medicinal Chemistry

We are looking for an Associate Director of Medicinal Chemistry to manage a lead optimization effort. We have a small team, so this is an opportunity to make a significant impact on the success and early trajectory of the company.

The successful candidate should have a doctoral degree in medicinal chemistry or a related field (Ph.D.) and at least 3 years (5+ years ideal) of commercial experience in pharmaceutical hit-to-lead optimization. Ideally, they will also have have excellent oral and written communication skills and be able to effectively manage a small team of chemists on a virtual basis. Experience in managing diverse teams as well as working collaboratively and effectively with contract research groups is required.

Job responsibilities:

• Manage lead optimization of a series of allosteric small molecule ligands

  • Design analogues and direct a small team of medicinal chemists in the synthesis of analogues
    • Ensure quality of work and data generated
    • Troubleshoot synthetic schemes as needed
    • Manage timelines for deliverables
    • Facilitate communications between chemists and serve as the primary point of contact with the CRO

• Work with computational biologists to design analogues to synthesize and test

• Work closely with patent team to expand intellectual property portfolio

• Contribute to early discovery programs in company pipeline

• Present results at technical meetings and to ViewPoint’s Board of Directors and Scientific Advisory Board

• Interact in a collaborative manner with other team members to accomplish organizational goals

Personal qualifications:

• Entrepreneurial spirit with willingness to work as a member of a small and versatile team

• Strong interpersonal skills and ability to instill and earn trust quickly with teams, partners, and collaborators.

• Strong leadership and motivational capabilities.

• Clear written and verbal communication skills. Must be able to communicate effectively with business partners, senior executive leadership, direct reports, and external collaborators clearly and credibly.

• Flexible and adaptable style, with a willingness to take on new challenges and resilience to respond to emerging challenges

• High level of integrity and honesty

ViewPoint is an equal opportunity employer.

Benefits:

Competitive salary, commensurate with experience

Stock compensation plan

Excellent health, dental, and vision benefits

Flexible work schedule

Job Type:

Full-time

If you are interested, we’d love to hear from you. Please forward all resumes with cover letters to:

jobs@viewpointtherapeutics.com

+ Research Scientist

ViewPoint is in search of a self-motivated, talented, entrepreneurial Research Scientist interested in joining a fast-paced and dynamic research group. The preferred candidate will be expected to design and carry out studies to characterize new drug candidates and elucidate their mechanism of action using biophysical, biochemical, and cellular biology techniques. Additionally, the candidate will be involved in early-stage studies to explore new indications that relate to ViewPoint’s focus on protein misfolding diseases.

The successful candidate should have a doctoral degree in biochemistry, biophysics, cellular biology, or related subject in the life sciences (Ph.D.) and at least 3 years of working in a biotechnology environment. Ideally, they will also have experience using biophysical/biochemical in vitro techniques and experience studying small molecules in cell models and systems.

Job responsibilities:

  • Characterize protein-ligand interactions and protein-protein interactions with biochemical and biophysical assays (e.g. DSF, SPR, MST, FRET, enzymatic)
  • Develop relevant cell models of protein misfolding diseases and characterize the activity of drug candidates using fluorescence microscopy, flow cytometry, or other relevant techniques
  • Keep an accurate and up-to-date laboratory notebook and contribute to periodic technical reports and manuscripts
  • Present results to project leaders and participate in discussions of research strategy on a routine basis
  • Interact in a collaborative manner with other team members to accomplish organizational goals


Job responsibilities may also include:

  • Develop quantitative biophysical ligand binding assays for use in driving medicinal chemistry optimization
  • Assist in characterizing small molecules using standard analytical techniques (e.g. HPLC/MS, proton and carbon NMR)
  • Dissect tissues and carry out assays using protein extracts
  • Dissect tissues and carry out ex vivo pharmacokinetic assessments
  • Present results at technical meetings and to ViewPoint’s Board of Directors and Scientific Advisory Board

Personal qualifications:

• Entrepreneurial spirit with willingness to work as a member of a small and versatile team

• Strong interpersonal skills and ability to instill and earn trust quickly with teams, partners, and collaborators.

• Strong leadership and motivational capabilities.

• Clear written and verbal communication skills. Must be able to communicate effectively with business partners, senior executive leadership, direct reports, and external collaborators clearly and credibly.

• Flexible and adaptable style, with a willingness to take on new challenges and resilience to respond to emerging challenges

• High level of integrity and honesty

ViewPoint is an equal opportunity employer.

Benefits:

Competitive salary, commensurate with experience

Stock compensation plan

Excellent health, dental, and vision benefits

Flexible work schedule

Job Type:

Full-time

If you are interested, we’d love to hear from you. Please forward all resumes with cover letters to:

jobs@viewpointtherapeutics.com

Projected start date: December 2018 or January 2019

+ Research Associate

ViewPoint is in search of a self-motivated, talented, detail-oriented Research Associate to join our discovery research group in a full-time position. We have a small team, so this is an opportunity to make a significant impact on the early trajectory of a venture-backed startup and to grow along with our company.

The successful candidate should have a bachelor of science degree in biochemistry, cellular biology, molecular biology, or related subject (BS) and at least 2 years of laboratory research experience. Ideally, they will also have have developed skills with in vitro protein characterization and/or cellular biology.

Job responsibilities:

  • Conduct recombinant protein production and purification
  • Assist with the preparation of reagents for biophysical and biochemical assays
  • Carry out biophysical and biochemical assays to characterize drug candidates
  • Maintain mammalian cell cultures and perform routine cytotoxicity experiments
  • Assist with studies using cultured cells, tissue extracts, and whole tissue
  • Analyze experimental data using GraphPad Prism and the Microsoft Office Suite
  • Keep an accurate, detailed, up-to-date laboratory notebook
  • Contribute to technical reports and manuscripts
  • Interact in a collaborative manner with team members to accomplish organizational goals

This list of job duties is not exhaustive and may be revised from time to time per business needs.

Personal qualifications:

  • Proven ability to perform experiments, analyze data, and perform troubleshooting without supervision when needed
  • Experience with programming (Python/R) and/or statistical analysis is a plus
  • Entrepreneurial spirit with willingness to work as a member of a small and versatile team
  • Strong interpersonal skills and ability to instill and earn trust quickly with teams, partners, and collaborators.
  • Strong leadership and motivational capabilities.
  • Clear written and verbal communication skills. Must be able to communicate effectively with business partners, senior executive leadership, direct reports, and external collaborators clearly and credibly.
  • Flexible and adaptable style, with a willingness to take on new challenges and resilience to respond to emerging challenges
  • High level of integrity and honesty

ViewPoint is an equal opportunity employer.

Benefits:

Competitive salary, commensurate with experience

Stock compensation plan

Excellent health, dental, and vision benefits

Flexible work schedule

Job Type:

Full-time

If you are interested, we’d love to hear from you. Please forward all resumes with cover letters to:

jobs@viewpointtherapeutics.com

Projected start date: December 2018 or January 2019